Solution:

In the realm of biotechnology, microbes are commonly utilized to produce primary and secondary metabolites. These have a wide range of applications in agriculture, medicine, and manufacturing. E.coli and Lactobacillus are two microorganisms that have made significant contributions to biotechnology. E.coli is commonly employed in the manufacture of proteins and genetic transformation. Lactobacillus is mostly utilized in the food industry for fermented foods and alcohol manufacturing.