◆Stirred tank bioreactors are developed for a large-scale production of biotechnology products but the shake flask method is used for a small-scale production of biotechnological products carried out in a laboratory.

 ◆Stirred tank bioreactor has few advantages over shake flasks. That are-

1. testing and sampling process, small amounts of culture can be drawn out from the reactor.

2.Presence of a control system to regulate the pH and temperature.

3.To regulate the foam, the stirred tank bioreactors have a foam breaker.